Table 2.
Studies addressing the effect of TAI on ovarian reserve/response and on assisted reproductive technology (ART) outcome.
| Author, year | Patients’ characteristics | Study outcomes | Thyroid function | Main conclusion |
|---|---|---|---|---|
| Polyzos, 2015 (69) | 5000 women, infertility work up/other reasons | TAI prevalence in women with variable OR | EU/SCH/OH | No difference of TAI in women with variable OR |
| Chen, 2017 (68) | 1044 women eligible for IUI/IVF | TAI prevalence in women with variable OR | EU | Idiopathic low OR associated with TAI |
| Korevar, 2018 (36) | 436 women (46 TAI+) infertility work up | Association of TAI with OR | EU | TAI associated with lower AFC in women with unexplained infertility or diminished OR |
| Weghofer, 2016 (70) | 225 women (25 TAI+) infertility work up | Association of TAI/TSH with OR | EU | TSH <3.0 mIU/L associated with higher OR |
| Magri, 2015 (66) | 288 women (55 TAI+), IVF | Ovarian response to COH | EU | Poorer ovarian response in TAI |
| Weghofer, 2016 (70) | 98 women (17 TAI+) with low OR, IVF | EQ | EU | Poorer embryo quality in TAI |
| Andrisani, 2018 (72) | 123 (29 TAI+), IVF/ICSI | EQ, IR, PR | EU | Poorer EQ in TAI, no differences in IR and PR |
| Poppe, 2003 (73) | 234 women (32 TAI+), IVF/ICSI | LBR, CPR, MR | EU | No difference in CPR in TAI, higher MR in TAI |
| Negro, 2005 (74) | 484 (72 TAI+), IVF/ICSI | PR, MR | EU | No difference in PR, higher MR in TAI |
| Negro, 2007 (77) | 416women (42 TAI+), IVF/ICSI | NOR, LBR, CPR, MR | EU | No effect on CPR |
| Tan, 2014 (86) | 835 women (110 TAI+), ICSI | CPR, MR, PTB | EU | No effect of TAI |
| Litwicka, 2015 (76) | 194 (60 TAI+), IVF | NOR, LBR, CPR, MR, | EU | Lower LBR, higher MR in TAI |
| Lukasuk, 2015 (26) | 573 (114 TAI+), ICSI | NOR, LBR, PR, MR, | EU | No effect on PR, LBR, MR, lower NOR in TAI |
| Unuane, 2016 (78) | 2406 women (33 TAI+), ICSI | LBR | EU | No effect of TAI |
| Unuane, 2017 (87) | 3143 women (187 TAI+), IUI | LBR, CPR, MR | EU | No effect of TAI |
| Poppe, 2020 (79) | 279 women, ART, IVF/ICSI | NOR, FR, EQ | EU/SCH | No effect of TAI/SCH |
| Hamad, 2021 (29) | 584 women (148 TAI+), IVF/ICSI | CPR | EU | No effect of TAI |
TAI, thyroid autoimmunity; OR, ovarian reserve; AFC, antral follicle count; EQ, embryo quality; NOR, number of oocytes retrieved; IR, implantation rate; CPR, clinical pregnancy rate; LBR, live birth rate; MR, miscarriage rate; EU, euthyroidism; SCH, subclinical hypothyroidism; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection.