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. 2022 May 26;12:835549. doi: 10.3389/fonc.2022.835549

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Copyright © 2022 Bao, Wang, Li, Gao, Zheng, Shen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Composition and structure of the mitochondrial ribosome. The mature mitochondrial ribosome, which consists of a large and a small subunit, is permanently anchored to the inner mitochondrial membrane by MRPL45 (mL45) of the large subunit. Mitochondrial ribosomal proteins are synthesized within the cytosol and enter mitochondria mediated by the transmembrane transport complex including Translocase of the Outer mitochondrial Membrane (TOM) and Translocase of the Inner Membrane (TIM). RNA components are encoded by mitochondrial DNA.