Table 1.
Association between mitochondrial ribosomal genes and cancer revealed by high-throughput sequencing.
| Sequencing Categories | Molecular Event | Molecular Signatures | Cancer | Reference |
|---|---|---|---|---|
| RNA sequencing | Differential Gene Expression | MRPL13 | Non-small cell lung cancer | (51) |
| MRPS6 MRPS10 MRPS31 | Breast cancer | (52, 53) | ||
| MRPS23 | Luminal breast cancer | (54, 55) | ||
| Colorectal cancer | (56) | |||
| MRPL54 | Hepatocellular carcinoma | (57, 58) | ||
| MRPS12 | Ovarian cancer | (59) | ||
| MRPS7 | Osteosarcoma | (60) | ||
| MRPL27 | Lung adenocarcinoma | (61) | ||
| MRPL9 | Hepatocellular carcinoma | (40) | ||
| MRPS18A | Cholangiocarcinoma | (62) | ||
| Gene Fusions | MRPS31-SUGT1 | Colorectal cancer | (63) | |
| MRPS30-ARID2 | Intimal sarcoma | (64) | ||
| LncRNAs | MRPL23-AS1 | Bladder cancer | (65) | |
| Hepatocellular carcinoma | (66) | |||
| LINC00152-USF1/MRPL52 | Oral squamous cell carcinoma | (67) | ||
| TRIM52-AS1-MRPS18A | Hepatocellular carcinoma | (68) | ||
| DNA sequencing | SNPs |
rs2839698-MRPL23-AS1
rs3024270 -MRPL23-AS1 |
Hepatoblastoma | (69) |
| rs4919510-MRPL43 | Colorectal cancer | (70) | ||
| Methylation | lnc-MRPL3-2 | Neuroblastoma | (71) |