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. 2022 May 26;12:774494. doi: 10.3389/fcimb.2022.774494

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Copyright © 2022 Liu, Xu, Guo, Liu, Qiao, Ge, Zheng and Gou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The genetic context of mcr-1 gene on p6S41-1 and p5ZF15-2-1. (A) Comparison of genes surrounding mcr-1 on p6S41-1, pMFDS1318.1 (accession number: MK875282), pWI2-mcr (accession number: LT838201) and pICBEC7Pmcr (accession number: CP017246). (B) Comparison of genes surrounding mcr-1 on p5ZF15-2-1, pAH01-2 (accession number: CP055253) and pGD65-3 (accession number: KY075661). Open reading frames (ORFs) are shown as arrows and indicated according to their putative functions. Purple indicates genes related to mobile elements, red indicates genes related to drug resistance, light yellow indicates genes related to plasmid stability, blue indicates genes involved in conjugation and orange represents other functional genes. Hypothetical protein encoded genes are colored by grey. Regions with a high degree of homology are indicated by pink shading.