Table 1. Characteristics of included studies.

Author	Year of publication	No. of patients	Dosage	Duration of treatment	Placebo-controlled
Wang et al. [4]	1983	18	25 mg/day	6 months	yes
Mičič et al. [5]	1985	101	50 mg/day	6-9 months	yes
Sokol et al. [6]	1988	20	25 mg/day	12 months	yes
Hommonai et al. [7]	1988	44	25 mg/day	4-5 months	no
Kim et al. [8]	2016	171	12.5/25 mg/day	17 weeks	yes
Surbone et al. [9]	2019	18	50 mg/48h	3 months	no
Sharma et al. [10]	2019	44	25 mg/day	2.8 months	no
Mandal et al. [11]	2020	200	25 mg/day	3 months	yes