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. 2022 May 26;12:883301. doi: 10.3389/fonc.2022.883301

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Copyright © 2022 Chen, Li, Wang, Wu, Zhang, Yan, Wei, Peng and Qi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hub lncRNA-LINC00654 identified using the public database. Batch Cox regression was performed to screen for independent risk lncRNAs, TOP three lncRNAs (lnc01545, lnc00654, and lnc00115) are selected (A–C), expression validation of three lncRNAs in TCGA database, two candidate lncRNAs were identify (lnc01545 and lnc00654) (D–F), random forest model was used to select important lncRNAs, the model error rate was 29.56%, seven lncRNAs are listed (KCNJ2-AS1, RUSC1-AS1, lnc00115, lnc00327, lnc00654, lnc01232, and JPX) (G, H) the Venn diagram shows that lnc00654 was identified as hub lncRNA.