Table 3.
Canonical pathways of differentially methylated positions (DMPs) in placental genes in GDM vs. control groups.
| Pathway | P* | Overlapped genes (ratio) |
|---|---|---|
| Bladder Cancer Signaling | 0.005 | 4/114 (0.035) |
| GABA Receptor Signaling | 0.008 | 4/130 (0.0308) |
| Uracil Degradation II (Reductive) | 0.023 | 1/4 (0.25) |
| Thymine Degradation | 0.023 | 1/4 (0.25) |
| CREB Signaling in Neurons | 0.025 | 8/591 (0.0135) |
| tRNA Splicing | 0.028 | 2/44 (0.0455) |
| Gustation Pathway | 0.030 | 4/197 (0.0203) |
| Amyotrophic Lateral Sclerosis Signaling | 0.031 | 3/114 (0.0263) |
| Cardiac Hypertrophy Signaling (Enhanced) | 0.039 | 7/527 (0.0133) |
| cAMP-mediated signaling | 0.047 | 4/226 (0.0177) |
*Crude p value from Fisher’s exact test.