Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 17;9:32. doi: 10.1186/s40779-022-00387-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Study design and flow diagram. A total of 35 confirmed patients were recruited and completed a 1-year follow-up after recovery. In addition, 160 healthy controls (HCs) were enrolled. A total of 497 samples were prospectively collected, including 219 tongue-coating samples, 129 stool samples and 149 plasma samples. In addition, 455 samples were included for further analysis after strict inclusion and exclusion criteria. 16S rRNA MiSeq sequencing was conducted on tongue-coating samples and stool samples, and untargeted metabolomics testing on liquid chromatography-mass spectrometry (LC–MS) analysis was carried out on plasma samples. CPR0 confirmed patients recover at discharge, CPR1 confirmed patients recover 1 year, HCs healthy controls, UPLC-MS ultra-performance liquid chromatography-mass spectrometry, RFC random forest model