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. 2022 Jun 17;9:32. doi: 10.1186/s40779-022-00387-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Gradual recovery of the oral microbiome. a Neutralizing antibodies and IgG gradually decreased from CPR0 to CPR1 to HC. b As estimated by the Shannon index, the oral microbial α diversity gradually increased. c The PCoA showed that the compositions and β diversity gradually recovered. d Key oral bacteria whose abundance gradually increased or decreased were identified at the phylum and genus levels among three groups. e Heatmap displays the gradual recovery of the key OTUs in the oral microbiome. ^**P < 0.01, ^***P < 0.001, compared among three groups. CPR0 confirmed patients recover at discharge, CPR1 confirmed patients recover 1 year, HC healthy control, PCoA principal coordinate analysis, OTUs operational taxonomy units