Table 3.
Immunotherapy duration, clinical follow-up, immunotherapy termination
Nivolumab+TACE (n=31) |
Nivolumab only (All matched n=104) |
||
Number (%) or median (Range) | P value | ||
Duration immunotherapy (months) | 8.3 (0.5–40.1) | 3.3 (0.4–35.9) | 0.009* |
Clinical follow-up after nivolumab initiation (months) | 12.6 (1.3–40.6) | 7.5 (0.5–47.8) | 0.26 |
Ongoing nivolumab at last follow-up | 13 (42) | 23 (22) | 0.04 |
Discontinued treatment | 18 (58) | 80 (77) | 0.07 |
Disease progression | 3 (9.7) | 39 (38) | 0.004* |
Study drug toxicity | 0 (0) | 9 (8.7) | 0.12 |
Complete Response | 1 (3.2) | 1 (1.0) | 0.41 |
Clinical deterioration | 4 (13) | 2 (1.9) | 0.03† |
Death | 5 (16)‡ | 3 (2.9) | 0.02† |
Other | 5 (16)§ | 14 (13)* | 0.77 |
*Statistically significant p-value <0.01
†Statistically significant p-value <0.05
‡2/5 deaths in setting of progression of disease
§4 patients successfully bridged to transplant.
TACE, transarterial chemoembolization.