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. 2022 Jun 16;10(6):e004205. doi: 10.1136/jitc-2021-004205

Table 3.

Immunotherapy duration, clinical follow-up, immunotherapy termination

Nivolumab+TACE
(n=31)
Nivolumab only
(All matched n=104)
Number (%) or median (Range) P value
Duration immunotherapy (months) 8.3 (0.5–40.1) 3.3 (0.4–35.9) 0.009*
Clinical follow-up after nivolumab initiation (months) 12.6 (1.3–40.6) 7.5 (0.5–47.8) 0.26
Ongoing nivolumab at last follow-up 13 (42) 23 (22) 0.04
Discontinued treatment 18 (58) 80 (77) 0.07
 Disease progression 3 (9.7) 39 (38) 0.004*
 Study drug toxicity 0 (0) 9 (8.7) 0.12
 Complete Response 1 (3.2) 1 (1.0) 0.41
 Clinical deterioration 4 (13) 2 (1.9) 0.03†
 Death 5 (16)‡ 3 (2.9) 0.02†
 Other 5 (16)§ 14 (13)* 0.77

*Statistically significant p-value <0.01

†Statistically significant p-value <0.05

‡2/5 deaths in setting of progression of disease

§4 patients successfully bridged to transplant.

TACE, transarterial chemoembolization.