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Optogenetic “sonar” method for targeting specific cellular populations for in vivo electrophysiology. Photostimulation “sonar” guides optrode to genetically targeted neurons expressing channelrhodopsin (ChR2) for extracellular electrophysiology recordings. Once the electrode is juxtaposed to a ChR2-expressing cell of interest, electrophysiological recordings may be performed. The optrode may have one or many channels for recording numerous cells simultaneously.
