TABLE 8.
Common chemogenetic receptors and ligands with their associated properties and effects on neuronal activity.
| Receptor name | Mechanism of action | Effect on neuronal firing | Ligand | References |
| hM3Dq | Phospholipase C Dependent (activator) | Increased | CNO/clozpine/JHU37152/ JHU37160/deschloroclozapine (DCZ) |
Alexander et al., 2009; Gomez et al., 2017; Bonaventura et al., 2019; Nagai et al., 2020 |
| hM1Dq | Phospholipase C Dependent (activator) | Increased | CNO | Alexander et al., 2009 |
| hM5Dq | Phospholipase C Dependent (activator) | Increased | CNO | Armbruster et al., 2007 |
| hM4Di | Adenylate Cyclyase Dependent (inhibitor) | Decreased | CNO/clozpine/JHU37152/ JHU37160/deschloroclozapine (DCZ) |
Zhu et al., 2014; Gomez et al., 2017; Matsui et al., 2018; Bonaventura et al., 2019; Nagai et al., 2020 |
| hM2Di | Adenylate Cyclyase Dependent (inhibitor) | Decreased | CNO | Armbruster et al., 2007 |
| Rq(R165L) | B-arrestin dependent | unknown | CNO | Nakajima and Wess, 2012 |
| KORD | Adenylate Cyclyase Dependent (inhibitor) | Decreased | Salvinorin B | Vardy et al., 2015 |
| PSAM-5HT3 | Ligand gated cation channel | Increased | varinicline | Magnus et al., 2019 |
| PSAM-GlyR | Ligand gated anion channel | Decreased | varinicline | Magnus et al., 2019 |