Table 2.
Binding parameters for interaction of nanoparticles with bNAb CR6261 measured by SPR and MST.
| Immunogen | Technique | Ligand | kon (M-1s-1) | koff (s-1) | KD (nM) |
|---|---|---|---|---|---|
| MsDps2- pH1HA10 | SPR | CR6261 | 4.5 ± 0.53×105 | 1.4 ± 0.13×10-3 | 3.2 ± 0.5 |
| MsDps2- pH1HA10 | MST | CR6261 | 1.1 ± 0.5 | ||
| MsDps2-pH1HA10 | SPR | CR9114 | 3.9 ± 0.3×105 | 1.7 ± 0.1×10-3 | 4.4 ± 0.3 |
| Encapsulin-pH1HA10 | SPR | CR6261 | 1.7 ± 0.3×105 | 9.6 ± 0.1×10-5 | 0.5 ± 0.1 |
| Encapsulin-pH1HA10 | MST | CR6261 | 9.1 ± 3.1 | ||
| Encapsulin-pH1HA10 | SPR | CR9114 | 1.1 ± 0.1×105 | 6.4 ± 0.18×10-3 | 5.5 ± 1.3 |
| pH1HA10-Ferritin | SPR | CR6261 | 3.1 ± 0.5×104 | No dissociation | No dissociation |
| pH1HA10-Ferritin | MST | CR6261 | 6 ± 1.2 |