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. 2022 May 26;9:898567. doi: 10.3389/fmolb.2022.898567

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Copyright © 2022 Peng, Du and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between RAB42 expression and immune cells infiltration in HCC. (A) Correlation analysis based on TIMER database showed RAB42 expression was positively correlated with tumor infiltrating lymphocytes in HCC tissues, including B cells, CD8⁺ T cells, CD4⁺ T cells, macrophages, neutrophils, and dendritic cells. Heat map showed the correlation between the RAB42 expression and various types of immune cells (B), immunoinhibitors (C), immunostimulators (D), chemokines (E), receptors (F) in HCC from the TISIDB database. The GEPIA database (G) and the TISIDB database (H) were used to evaluate the relationship between RAB42 expression and major immune checkpoint molecules in HCC, including PDCD1, CTLA-4, HAVCR2, LAG3, TNFRSF18 and TIGIT.