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. 2022 May 26;9:898567. doi: 10.3389/fmolb.2022.898567

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Copyright © 2022 Peng, Du and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between the methylation level of RAB42 with immune cells infiltration in HCC. (A) Heatmap showed the correlation of RAB42 methylation status with immune-infiltrating lymphocytes in HCC. RAB42 methylation status was negatively associated with gdT helper cells, Activated CD4⁺ T, T follicular helper cells, and Type 2 T helper cells in HCC from the TISIDB database. RAB42 methylation status was negatively correlated with immune checkpoint molecules (TNFRSF18, CD86, ICOS, CD80) (B), immunoinhibitors (PDCD1, CTLA4, LAG3, TIGIT) (C), chemokines (XCL1, CCL20, CXCL5, CCL8) (D) and receptors (CXCR4, CXCR3, CCR10, CCR6) (E) in HCC from the TISIDB database.