Table 2. Objective Response Rate, Progression-Free, and Overall Survival to PD-1/PD-L1 Blockade in High and Low TMB Non–Small Cell Lung Cancer According to PD-L1 Expression Subgroups.

Outcome and PD-L1 tumor proportion score	Low TMB	High TMB	P value
Objective response rate, % (95% CI)
<1%	8.7 (5.5-12.9)	46.7 (28.3-65.7)	<.001
1%-49%	18.7 (14.1-23.9)	50.0 (31.3-68.7)	<.001
≥50%	38.1 (33.3-43.0)	56.5 (41.1-71.1)	.02
Progression-free survival, median (95% CI), mo
<1%	2.1 (2.0-2.4)	10.7 (8.2-24.4)	<.001
1%-49%	2.9 (2.5-3.6)	13.6 (8.6-NR)	<.001
≥50%	5.2 (4.6-6.2)	18.1 (8.6-NR)	<.001
Overall survival, median (95% CI), mo
<1%	10.4 (7.9-13.6)	23.9 (16.7-NR)	.07
1%-49%	11.3 (9.6-14.7)	NR (21.2-NR)	<.001
≥50%	21.4 (17.5-25.9)	47.7 (35.4-NR)	.02

Abbreviations: NR, not reached; PD-1, programmed cell death–1; PD-L1, programmed death ligand–1; TMB, tumor mutation burden.