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. Author manuscript; available in PMC: 2022 Jun 17.
Published in final edited form as: Exp Neurol. 2019 Oct 31;323:113083. doi: 10.1016/j.expneurol.2019.113083

Figure 6. Effects of GBP on hypertension induced by noxious colorectal distension.

Figure 6.

Autonomic dysreflexia was experimentally induced on 14, 21- and 28-days post-injury (DPI) through noxious colorectal distension (CRD). GBP significantly reduced both the (A) absolute mean arterial pressure (MAP) reached during CRD across DPI. (B) The baseline MAP calculated from the 30 seconds immediately prior to each CRD trial was significantly lower in GBP treated rats. (C) The CRD-induced change in MAP relative to baseline was not different between groups, however this parameter increased significantly over time. (D) CRD-induced changes in heart rate were not significantly altered by GBP over time. N=11 Saline, N=10 GBP. Bars are mean ± SD. *p<0.05 vs saline.