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. 2021 Jul 19;33(6):1069–1079. doi: 10.1021/acs.bioconjchem.1c00203

Figure 3.

Figure 3

Optimization results in tissue mimicking phantoms. (A) Diluted microbubble (MB) solution is injected into a rod inclusion in an agarose cube that is placed at the focal region of a dual imaging-therapy setup. (B) Inclusion signal as a function of MB concentration. (C) Ultrasound (US) images of the MB-filled inclusion before and after application of a therapeutic US treatment with center frequencies of 250 kHz (either 180 or 290 kPa) and 80 kHz (either 50 or 120 kPa). (D) Impact of treatment duration on the contrast reduction for peak negative pressures (PNP) of 65, 110, and 180, representing stable cavitation, and 290 kPa, representing inertial cavitation and a center frequency of 250 kHz. (E) Contrast reduction as a function of PNP for MB only and cells + targeted MBs (TMB), for the two center frequencies. All experiments were performed in triplicate. All data are plotted as mean ± SD.