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. 2022 Jun 2;16:877094. doi: 10.3389/fnbeh.2022.877094

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Copyright © 2022 Reiber, Stirling, Sprengel, Gass, Palme and Potschka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bench-top assessment focusing on overall activity. We analyzed the overall activity focusing on the total distance moved and the velocity of movement in the PhenoTyper cages. The distance moved by prepubescent (A) and sexually mature (B) mice during the 60-min observation interval was significantly affected by genotype only in sexually mature mice. For the velocity of movement in prepubescent (C) and sexually mature (D) mice, a significant effect of genotype could not be confirmed. ANOVA, followed by FDR correction. n = 8–10 per genotype per sex. *p < 0.05. Error bars indicate the standard error of the mean (SEM).