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. 2022 Jun 2;16:877094. doi: 10.3389/fnbeh.2022.877094

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Copyright © 2022 Reiber, Stirling, Sprengel, Gass, Palme and Potschka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Open field test – total monitoring duration. During the total observation period of 15 min, Gria1^–/– mice moved a greater distance than wild-type littermates during prepubescence (A) as well as once sexually mature (B). Considering velocity of movement, Gria1^–/– mice moved with increased speed as compared to age-matched wild-types during prepubescence (C) and once sexually mature (D). Considering states of immobility displayed by the mice, there were significant effects of genotype demonstrating that Gria1^–/– mice showed a shorter immobility duration than wild-type littermates during prepubescence (E) and once sexually mature (F). ANOVA, followed by FDR-correction. n = 8–10 per genotype per sex. *p < 0.05. Error bars indicate the standard error of the mean (SEM).