FIGURE 8.

Open field test – monitoring of the first 5 min. Analysis of the first 5 min after exposure to the open field arena revealed that there was a significant effect of genotype and a significant genotype by sex interaction in prepubescent mice indicating that female Gria1^–/– mice spent more time in the zone “wall” than female wild-type littermates (A). In sexually mature mice, groups were statistically similar in the duration spent in the zone “wall” (B). Considering the duration prepubescent (C) and sexually mature (D) mice spent in the zone “center” of the arena, there was a significant effect of genotype in prepubescent mice demonstrating that prepubescent Gria1^–/– mice spent less time in the zone “center” than wild-type littermates. ANOVA, followed by FDR correction or Bonferroni multiple comparison post hoc tests. n = 8–10 per genotype per sex. *p < 0.05. Error bars indicate the standard error of the mean (SEM).