Extended Data Table 4 ∣.
Description of SARS-CoV-2 S-binding mAbs derived from GC B cells and LNPCs
| 01a (N=145) N (%) |
02a (N=410) N (%) |
04 (N=124) N (%) |
07 (N=201) N (%) |
10 (N=249) N (%) |
13 (N=108) N (%) |
20 (N=99) N (%) |
22 (N=167) N (%) |
||
|---|---|---|---|---|---|---|---|---|---|
| Heavy chain isotype | IGHG | 109 (75.2%) | 387 (94.4%) | 102 (82.3%) | 146 (72.6%) | 200 (80.3%) | 102 (94.4%) | 90 (90.9%) | 144 (86.2%) |
| IGHA | 35 (24.1%) | 11 (2.7%) | 15 (12.1%) | 54 (26.9%) | 43 (17.3%) | 5 (4.6%) | 6 (6.1%) | 22 (13.2%) | |
| IGHM | 1 (0.7%) | 11 (2.7%) | 7 (5.6%) | 1 (0.5%) | 2 (0.8%) | 1 (0.9%) | 3 (3%) | 1 (0.6%) | |
| IGHD | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | |
| Light chain isotype | IGKC | 102 (70.3%) | 223 (54.4%) | 61 (49.2%) | 133 (66.2%) | 183 (73.5%) | 66 (61.1%) | 69 (69.7%) | 73 (43.7%) |
| IGLC | 43 (29.7%) | 187 (45.6%) | 63 (50.8%) | 68 (33.8%) | 66 (26.5%) | 42 (38.9%) | 30 (30.3%) | 94 (56.3%) | |
| Compartment | GC B cell | 85 (58.6%) | 248 (60.5%) | 95 (76.6%) | 134 (66.7%) | 151 (60.6%) | 68 (63%) | 59 (59.6%) | 82 (49.1%) |
| LNPC | 60 (41.4%) | 162 (39.5%) | 29 (23.4%) | 67 (33.3%) | 98 (39.4%) | 40 (37%) | 40 (40.4%) | 85 (50.9%) | |
| Time point | Week 4 | 45 (36.3%) | |||||||
| Week 5 | 180 (43.9%) | ||||||||
| Week 7 | 84 (57.9%) | 230 (56.1%) | 79 (63.7%) | 142 (70.6%) | 115 (46.2%) | 67 (62%) | 34 (34.3%) | 108 (64.7%) | |
| Week 15 | 61 (42.1%) | 59 (29.4%) | 134 (53.8%) | 41 (38%) | 65 (65.7%) | 59 (35.3%) |