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. 2022 Apr 6;2(3):241–250. doi: 10.1021/acsmeasuresciau.1c00060

Figure 5.

Figure 5

Comparison between linear regression and standardized neural network for in vivo serotonin ambient predictions. (A,B) Mean ± SEM (n = 5 animals) concentration vs time trace of basal serotonin recorded in the CA2 region of the hippocampus. In part A, the calibration was performed using an electrode-specific post-calibration. In (B), the predictions were obtained from the standardized neural network by feeding the totality of the CV to the model. Mice were injected with a saline solution at 30 min and the SSRI, escitalopram (ESCIT) (10 mg/kg) solution at 60 min. (C) Representative concentration vs time FSCAV acquisition in the CA2 region of the hippocampus using manual analysis (blue) and the automatic calibration using standardized neural networks (red). Mouse was injected with a lipopolysaccharide solution (0.2 mg/kg) at 30 min and ESCIT (10 mg/kg) solution at 60 min.