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. 2022 Jun 16;15:65. doi: 10.1186/s13068-022-02166-2

Table 1.

ɛ-PL-producing strains and its fermentation performance

Strains(Origin) Carbon and nitrogen sources Fermentation strategy Yield (g/L) Productivity (g/L/h) Detection method Refs.
Streptomyces sp. M-Z18 (China) Glycerol + fish meal + corn steep liquor Addition of talc microparticles and acidic pH shock 62.36 0.329 Methyl orange precipitation method [92]
Streptomyces albulus FEEL-1 (China) Glucose + yeast extract Introducing related antibiotics 59.50 8.21 g/L/day Methyl orange precipitation method [145]
Streptomyces albulus W-156 (China) Glycerol + yeast extract Combining genome shuffling and gentamicin resistance 56.5 0.226 Methyl orange precipitation method [76]
Streptomyces sp. AF3-44 (China) Glycerol + yeast extract Addition of exogenous glutathione 46.5 0.277 Methyl orange precipitation method [104]
Streptomyces sp. FEEL-1 (China) Glycerol + yeast extract Screening by ARTP mutagenesis with streptomycin resistance 41.2 0.245 Methyl orange precipitation method [75]
Streptomyces sp. M-Z18 (China) Glycerol + beef extract Screening ɛ-PL-tolerant strain by genome shuffling 39.96 0.231 Methyl orange precipitation method [142]
Streptomyces sp. M-Z18 (China) Industrial glycerol + beef extract Through seed stage with in situ pH monitoring 36.22 0.195 Methyl orange precipitation method [143]
Streptomyces griseofuscus (China) Glucose + yeast extract Addition of exogenous astaxanthin 36.1 0.188 Methyl orange precipitation method [149]
S. albulus PD-1 (China) Glucose + yeast extract Overexpression of ammonium transporter gene 35.7 0.213 High-performance liquid chromatography [146]
S. albulus PD-1 (China) Glucose + yeast extract Expression of VHb gene 34.2 0.204 High-performance liquid chromatography [87]
Kitasatospora sp. MY 5–36 (China) yeast extract + glucose Immobilization on loofah sponge 34.11 9.34 g/L/day High-perfor-mance liquid chromatography [106]
S. albulus LS-84 (China) Glucose + yeast extract + CSR Intergeneric hybridization 32.6 0.166 Methyl orange precipitation method [131]
S. albulus M-Z18 (China) Glucose + yeast extract Applying a novel two-stage fermentation 32.22 5.86 g/L/day Methyl orange precipitation method [82]
Streptomyces ahygroscopicus GIM8 (China) Glucose + yeast extract One-Stage pH Control coupled with Nutrient Feeding 28.2 0.098 High-performance liquid chromatography [97]
Streptomyces. sp. GIM8 (China) Glucose + yeast extract Resin-based in situ product removal strategy 23.4 0.117 Methyl orange precipitation method [107]

Streptomyces albulus CICC

11,022 (China)

Glucose + yeast extract OverexpressionofPLs and sodium citrate feeding 20.1 6.7 g/L/day Mmethyl orange precipitation method [101]
S. albulus S410 (Japan) Glucose + yeast extract A two stages pH control strategy 48.3 0.252 Methyl orange precipitation method [77]
S. albulus NBRC14147 (Japan) Polypeptone + yeast extract + sucrose Inactivation of concomitant biosynthetic pathways About 3.60 0.129 Methyl orange precipitation method [14]
Streptomyces noursei NRRL 5126 (India) proteose peptone, glycerol Using the resting cell culture technique 2.36 0.028 Calorimetric determination by trypan blue precipitation [144]
Bacillus cereus sp. (India) Glucose + yeast extract Adding metabolic precursors 0.565 0.006 Methyl orange precipitation method [147]
Bacillus licheniformis L26 (India) crude glycerol + peptone + yeast extract Optimization of medium 155 mg/L 0.0013 Trypan blue precipitation method [48, 148]