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Schematic model of miR-1248 oncogenic role in pLGGs. a p21 inhibition by miR-1248 leads to cell proliferation, impaired DNA repair and escape from oncogene induced senescence. b miR-1248 maintains low FRK levels promoting migration, invasion and growth. c miR-1248 targeting of VHL contributes to angiogenesis, cell proliferation and escape from the apoptotic program
