Table 3.
Overview of the 10 miR-1248 validated target genes included in the TSGene 2.0 database
| Official symbol | Official full name | Sequence accession ID | Function |
|---|---|---|---|
| ANAPC1 | Anaphase promoting complex subunit 1 | NM_022662.4 | ANAPC1 is a component of the anaphase-promoting complex, an E3 ubiquitin ligase complex that controls progression through the metaphase to anaphase of the cell cycle |
| CDKN1A | Cyclin-dependent Kinase Inhibitor 1A | NM_000389.4 | P21 acts as a regulator of cell cycle progression at G1 in a p53-dependent and independent way. P21 plays regulatory roles in S phase DNA replication and DNA damage repair |
| FRK | Fyn-related SRC Family Tyrosine kinase | NM_002031.2 | FRK suppresses cell growth and promotes PTEN protein stability. FRK may function as a tumour suppressor protein |
| HIVEP3 | HIVEP zinc-finger 3 | NM_001127714.3 | HIVEP3 is a transcription factor that inhibits TNF-α induced NF-κB activation. HIVEP3 may interacts with TRAF proteins inhibiting the c-Jun/JNK signalling pathway |
| MTAP | S-methyl-5'-thioadenosine phosphorylase | NM_002451.3 | MTAP is an enzyme involved in polyamine metabolism and its down-regulation and/or deletion has been described in many cancers |
| NOTCH2 | Notch receptor 2 | NM_001200001.2 | NOTCH2 belongs to an evolutionarily conserved intercellular signalling pathway with roles in cell fate decisions, such proliferation, differentiation and apoptosis |
| PRKCB | Protein kinase C beta | NM_002738.7 | PRKCB is a serine/threonine protein kinase involved in several cellular processes, such as oxidative stress induced apoptosis, insulin signalling and glucose transport regulation |
| SH2B3 | SH2B adaptor protein 3 | NM_001291424.1 | SH2B3 is a negative regulator of cytokine signalling with critical roles in hematopoiesis |
| SPOP | Speckle-type POZ protein | NM_001007226.1 | SPOP is a member of the E3 ubiquitin-protein ligase complex and mediates the ubiquitination and subsequent degradation of target proteins |
| VHL | von Hippel-Lindau disease tumor suppressor | NM_000551.3 | VHL is a member of a protein complex with ubiquitin ligase E3 activity, being involved in the ubiquitination and degradation of hypoxia-inducible factors |