Table 1.
Baseline characteristics
| Amulet | Wachman | p value | |
|---|---|---|---|
| LAA closure | |||
| Total population | 93 | 389 | |
| Sex, male N (%) | 56 (58%) | 256 (66%) | 0.310 |
| Alter | 74.41 ± 8.775 | 75.09 ± 8.537 | 0.500 |
| CHA2DS2-VASc (Punkte) | 4.22 ± 1.548 | 4.04 ± 1.546 | 0.334 |
| HAS-BLED | 3.34 ± 1.238 | 3.62 ± 1.105 | 0.051 |
| LVEF (%) | 55.62 ± 9.740 | 53.75 ± 10.491 | 0.101 |
| LAA ostial diameter (mm) | 17.97 ± 3.038 | 19.72 ± 3.463 | 0.105 |
| AF paroxysmal | 39 (45.3%) | 171 (43.4%) | 0.500 |
| AF persistent | 21 (19.8%) | 70 (18.2%) | 0.310 |
| AF permanent | 30 (28.3%) | 148 (38.4%) | 0.229 |
| GFR prior to implantation | 61.91 ± 26.834 | 59.01 ± 24.551 | 0.343 |
| Indication for LAA closure | |||
| Intracranial bleeding | 26 (25%) | 111 (29%) | 0.533 |
| Gastrointestinal bleeding | 28 (26%) | 128 (33%) | 0.171 |
| Urogenital bleeding | 8 (08%) | 23 (6%) | 0.342 |
| Other bleeding | 12 (11%) | 49 (13%) | 0.789 |
| High bleeding risk | 1 (1%) | 10 (3%) | 0.386 |
| Reccurent falls | 1 (1%) | 5 (1%) | 0.870 |
| Lack of compliance | 1 (1%) | 3 (1%) | 0.772 |
| Cognitive deficit | 0 (00%) | 5 (1%) | 0.272 |
| NSAID/Steroid intake | 2 (2%) | 0 (00%) | 0.004 |
| Hemodialysis | 2 (2%) | 4 (1%) | 0.381 |
| Other contraindication | 10 (9%) | 28 (7%) | 0.644 |
| Patient request | 0 (00%) | 10 (3%) | 0.118 |
| Left atrial appendage isolation | 2 (02%) | 2 (1%) | 0.118 |
| Intraatrial thrombi despite OAK | 8 (8.6%) | 7 (1.799%) | 0.001 |
| Anticoagulation | |||
| ASA monotherapy | 11 (11.3%) | 34 (8.8%) | 0.358 |
| VKA monotherapy | 12 (12.3%) | 72 (18.7%) | 0.183 |
| DOAK monotherapy | 50 (48.1%) | 170 (44.2%) | 0.080 |
| LMWH/Fondaparinux monotherapy | 6 (8.5%) | 41 (10.1%) | 0.233 |
| Dual antiplatelet | 1 (1.9%) | 11 (2.6%) | 0.330 |
| VKA + antiplatelet | 0 (0.0%) | 9 (2.3%) | 0.139 |
| DOAK + antiplatelet | 7 (6.6%) | 11 (2.9%) | 0.032 |
| LMWH + antiplatelet | 1 (0.9%) | 3 (0.8%) | 0.396 |
| Triple therapy | 0 (0.0%) | 8 (2.1%) | 0.163 |
| No anticoagulation | 6 (6.6%) | 26 (6.8%) | 0.936 |
| Co morbidities | |||
| Ischemic stroke or TIA | 25 | 117 | 0.534 |
| Diabetes mellitus | 34 | 165 | 0.303 |
| Vascular Disease | 25 | 88 | 0.037 |
| Hypertension | 88 | 369 | 0.849 |
| Congestive heart failure | 11 | 95 | 0.027 |