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. 2022 Jun 17;12:90. doi: 10.1186/s13578-022-00832-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The proteomic analysis of C3aR blockade in the prefrontal cortex against depression. Sucrose preference (A). Peptide length distribution (B). Protein molecular distribution (C). Volcano plot of significant change proteins between Control and CUMS mice (D). Volcano plot of significant change proteins between CUMS and C3aR blockade mice (E). Venn diagram of significant change proteins between Control and CUMS mice (F). Venn diagram of significant change proteins between CUMS and C3aR blockade mice (G). The heat map of the significant change proteins between Control and CUMS mice (H). The heat map of the significant change proteins between CUMS and C3aR blockade mice (I). Data from Panel A were obtained from 9 mice per group. Data from Panels B–I were obtained from 3 samples (three mice per sample) per group. ^##P < 0.01 versus the Control group. ^**P < 0.01 versus the CUMS group