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. 2022 Jun 17;12:90. doi: 10.1186/s13578-022-00832-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — C3aR blockade inhibited synaptic pruning in the prefrontal cortex of CUMS mice. Representative photographs of Iba1(red)/PSD95(green)/DAPI(blue) and the 3D reconstruction (A). Representative photographs of Iba1(red)/synaptophysin (green)/DAPI(blue) and the 3D reconstruction (B). C3aR blockade restored the microglial morphology (C-H), prevented the engulfment of PSD95 by microglia according to area (I) and volume (J) analysis, and prevented the engulfment of synaptophysin by microglia according to area (K) and volume (L) analysis. Representative photographs of dendritic spines by Golgi staining (M). C3aR blockade enhanced dendritic spines in CUMS-induced mice (N). Data were obtained from 5 samples per group. ^##P < 0.01 versus the Control-vehicle group. ^*P < 0.05 and ^**P < 0.01 versus the CUMS-vehicle group