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MIR4435-2HG exerts its oncogenic role via different mechanisms in the progression of GC. MIR4435-2HG acts as a molecular sponge for miR-497 and miR-138-5p; therefore, it enhances the expression of NTRK3 and SOX4 (respectively), which results in cell proliferation, migration, and invasion. Also, an elevated level of MIR4435-2HG activates the TGF-β/SMAD signaling pathway, promotes EMT and suppresses apoptosis
