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. 2022 Jun 17;22:215. doi: 10.1186/s12935-022-02633-8

Fig. 4.

Fig. 4

The role of MIR4435-2HG in the pathogenesis of ovarian and breast cancers. In ovarian cancer, MIR4435-2HG regulates migration, invasion and apoptosis through modulating the expression of CDK14. The effect of MIR4435-2HG is exerted via sponging miR-128-3p. In addition, MIR4435-2HG enhances the progression of ovarian cancer via activation of the TGF-β signaling pathway. In breast cancer, MIR4435-2HG sponges miR-22-3p and results in a subsequent increase in TMEM9B expression and tumorigenesis