Table 1.

MIR4435-2HG participates in the pathogenesis of different cancers via the regulation of different miRNAs (∆: knock-down, EMT: Epithelial-Mesenchymal Transition, TNBC: Triple‐negative breast cancer, NSCLC: non‑small cell lung cancer, HNSCC: head and neck squamous cell carcinoma)

Cancer type	MIR4435-2HG	miRNA	Target gene	Function	References
Colorectal cancer	Up-regulated	↓miR-206	↑YAP1	∆ MIR4435-2HG: ↓Invasion, ↓Migration, ↓Cell proliferation, ↓EMT, ↓CRC growth, ↓Liver metastasis	[18]
Gastric cancer	Up-regulated	↓miR-497	↑ NTRK3	∆ MIR4435-2HG: ↓Cell proliferation, ↓Metastasis, ↑Apoptosis	[28]
Gastric cancer	Up-regulated	↓miR-138-5p	↑SOX4	∆ MIR4435-2HG: ↓Invasion, ↓Migration, ↓Cell proliferation, ↓EMT, ↑Apoptosis, ↓Tumor growth	[29]
Hepatocellular carcinoma	Up-regulated	↑miRNA-487a	–	↑MIR4435-2HG: ↑miRNA-487a, ↑Cell proliferation,	[35]
Hepatocellular carcinoma	Up-regulated	↓miR‑136‑5p	↑B3GNT5	∆ MIR4435-2HG: ↓Invasion, ↓Migration, ↓Cell proliferation	[38]
NSCLC	Up-regulated	↓miR-6754-5p	–	∆ MIR4435-2HG: ↓Invasion, ↓Migration, ↓Cell proliferation, ↑Apoptosis	[45]
Breast cancer	Up-regulated	↓miR-22-3p	↑TMEM9B	∆ MIR4435-2HG: ↓viability, ↓Invasion, ↓Migration, ↓Cell proliferation, ↓EMT	[48]
Ovarian cancer	Up-regulated	↓miR-128-3p	↑CDK14	∆ MIR4435-2HG: ↓Cell proliferation, ↓Invasion, ↓Migration, ↓Tumor growth, ↑Apoptosis	[51]
Glioma cancer	Up-regulated	↓miR-1224-5p	↑TGFBR2	∆ MIR4435-2HG: ↓Cell proliferation, ↓Invasion, ↓Tumor growth	[58]
Glioma cancer	Up-regulated	↓miR- 125a- 5p	↑TAZ	∆ MIR4435-2HG: ↓Migration, ↓Cell proliferation, ↑Apoptosis, ↓Wnt pathway, ↓Tumor volume	[61]
Cervical cancer	Up-regulated	↓miR-128-3p	↑MSI2	∆ MIR4435-2HG: ↓Cell proliferation, ↓Invasion, ↓Migration	[66]
Bladder cancer	Up-regulated	↓miR-4288	–	∆ MIR4435-2HG: ↓Cell proliferation, ↓Invasion, ↓Migration	[71]
HNSCC	Up-regulated	↓miR‑383‑5p	↑RBM3	∆ MIR4435-2HG: ↓Cell proliferation, ↓Invasion, ↓Migration, ↓EMT, ↓Tumor growth	[70]
Melanoma	Up-regulated	↓miR-802	↑FLOT2	↑MIR4435-2HG: ↑Cell proliferation, ↑Invasion, ↑Migration	[72]
TNBC	Up-regulated	↑miRNA‐21	-	↑MIR4435-2HG: ↑cell viability, ↑cell proliferation, ↑chemoresistance	[49]
NSCLC	Up-regulated	↓miRNA-204	↑CDK6	∆ MIR4435-2HG: ↓cell proliferation, ↓invasion, ↓migration	[46]