Table 2.

Diagnostic value of MIR4435-2HG in cancers and non-cancerous conditions [ALL: Acute lymphoblastic leukemia, AUC: Area under the Curve]

Disease	Expression	Number of samples	Sensitivity	Specificity	AUC	Sample	References
Gastric cancer	Up	51 cancer patients and 53 healthy controls	90.2	74.5	88.2	Plasma	[26]
Gastric cancer	Up	72 cancer patients and adjacent non-cancerous tissues	80	70	83.1	Serum	[27]
Hepatocellular cancer	Up	58 cancer patients and 45 healthy controls	75.9	95.9	91	Serum	[36]
Colorectal cancer	Up	70 cancer patients and adjacent non-cancerous tissues	72	80	81	Tissue	[21]
Colon cancer	Up	46 cancer patients and 42 healthy controls	–	–	84.8	Serum	[20]
Ovarian carcinoma	Up	66 cancer patients and 54 healthy controls	–	–	88.2	Plasma	[50]
ALL	Up	32 cancer patients and 32 healthy controls	–	–	89.5	Bone marrow	[64]
Renal cell carcinoma	Up	118 cancer patients and adjacent non-cancerous tissues	–	–	94.6	Tissue	[67]
Osteoarthritis	Down	78 osteoarthritis and 58 healthy controls	–	–	96	joint fluid	[14]
Osteoporosis	Down	88 osteoporosis patients and 57 healthy control	–	–	92	plasma	[15]
Non-traumatic ONFH	Down	36 ONFH patients and 30 healthy controls	–	–	81.8	Serum	[13]