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. 2022 Jun 3;12:896972. doi: 10.3389/fcimb.2022.896972

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Copyright © 2022 Andrade, de Souza, Torres, de Lima, Ebram, Celano, Schattner and Chudzinski-Tavassi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The SARS-CoV-2’s spike protein interacts with ACE-2 and allows SARS-CoV-2 infection. This infection causes activation of the endothelium and, subsequently, increases prothrombotic factors. The infection also enhances inflammation, which further damages the endothelium. ACE-2, angiotensin converting enzyme 2; KKS, Kallikrein-kinin system; RAS, renin-angiotensin system; BK, bradykinin; vWF, von Willebrand factor; PAI-1, plasminogen activator inhibitor–1; TF, Tissue factor. Image created in: biorender.com.