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. Author manuscript; available in PMC: 2022 Jun 17.
Published in final edited form as: Exp Eye Res. 2020 Nov 16;202:108361. doi: 10.1016/j.exer.2020.108361

Fig. 2.

Fig. 2.

Zinc finger nucleases. ZFNs are specifically designed to target and bind a region of DNA with FokI. Cleavage by FokI promotes double strand breaks and either non-homologous end joining pathway (NHEJ) or homology directed repair (HDR) ensues. NHEJ results in insertions or deletions that lead to a frameshift or gene disruption, while HDR leads to genome repair or insertion of a desirable gene to improve function. Reprinted with permission from Raikwar SP et al. World J. of Transl. Med. 2016; 5(1):1–13.