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. 2022 Jun 3;13:890027. doi: 10.3389/fimmu.2022.890027

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Copyright © 2022 Jadeja and Tobin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) AA patient #1 and (B) AA patient #2. AA serum IgG (green) and anti-TCHH (red) antibody colocalization in the anagen hair bulb (normal human scalp, 20x) as indicated by yellow/orange staining (white arrows). The white circle with yellow arrows highlights to AA serum IgG antibody binding to antigens located in the so-called ‘ring of fire’ redox-active zone of the HF (78). DP, Dermal Papilla; CTS, Connective Tissue Sheath; Mx, Matrix; IRS, Inner root sheath; He, Henle’s layer; Hx, Huxley’s layer.