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. 2022 Jun 3;13:857765. doi: 10.3389/fendo.2022.857765

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Copyright © 2022 Ji, Fu, Li, He and Qiu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fat mass and obesity-associated protein (FTO) effects on the transcription profile of papillary thyroid carcinoma (PTC) cells by RNA-seq. (A, B) A volcano plot shows the statistically upregulated (red) and downregulated (blue) genes between PTC-1-vector cells (control) and PTC-1-Lv-FTO cells (FTO overexpression), logFC <-1 or logFC >1, p 0.05, false discovery rate <0.05. (C) Signal pathways related to upregulated and downregulated genes reveal the role of differentially expressed genes in signal transduction. (D) The Kyoto Encyclopedia of Genes and Genomes analysis shows that FTO-over-expressed regulatory pathways are involved in cell proliferation, cell cycle, and apoptosis. (E) Gene ontologies related to the upregulated and downregulated genes between PTC-1-vector cells (control) and PTC-1-Lv-FTO cells (FTO overexpression).