Table 4.

Mean survival time of mice treated with leaf extract and fractions of S. officinarum during established P. berghei infection in mice.

Treatment	Dose (mg/kg)	Mean survival time (days)	% Parasitaemia on D7	Chemosuppression (%)
Control	–	12.5 ± 0.3	31.7 ± 2.4	–
Crude extract	170	18.3 ± 0.8b	14.5 ± 1.6c	54.1
	340	19.5 ± 1.0c	13.7 ± 1.3c	56.8
	510	21.3 ± 1.5c	11.5 ± 2.78 c	63.9
n-Hexane fraction	340	19.8 ± 0.8c	15.0 ± 1.86b	52.6
DCM fraction	340	20.8 ± 0.8c	12.2 ± 1.3c	61.5
Ethyl acetate fraction	340	20.0 ± 0.0c	12.5 ± 0.9c	60.7
n-Butanol fraction	340	23.0 ± 1.1c	10.5 ± 2.4c	66.9
Chloroquine	5	28.5 ± 1.2c	1.1 ± 0.9c	96.7

Values are expressed as mean ± SEM. Significance relative to control. ^ap < 0.05; ^bp < 0.01; ^cp < 0.001. n = 6.