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. 2022 May 31;13:779264. doi: 10.3389/fendo.2022.779264

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Copyright © 2022 Zhang, Zhao, Li, Geng, Zhao, Yang, Lv and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characteristics of the studied groups. (A) Spine L1-4 BMD and Femoral neck BMD. (B) Bone metabolic markers [25(OH)VD, β-CTX, RANKL/OPG]. (C) Plasma levels of TNF-α and IFN-γ secreted by Th1. (D) Plasma levels of IL-6 and IL-10 secreted by Th2. (E) CD4⁺CD25⁺CD127^-/low Treg cells. *p < 0.05, **p < 0.01, ^# p < 0.017 (^# p < 0.017, was considered significant, the test level needed to be adjusted for multiple pairwise comparisons of data, inspection level α’= inspection level α/times of comparison). NS, No statistical differences. Data are Mean± SD or Mean ± Q.