Table 1.

Topical therapies for oral mucosal cGVHD.

Topical Therapies	Standard Instructions:
Rinses: • Budesonide 0.03%* • Dexamethasone 0.01%* • Clobetasol propionate 0.05%* • Tacrolimus solution 0.1%* • Cyclosporine 100 mg/ml# • Azathioprine 5 mg/ml#	Rinse and hold 5 to 10 mL for 3 to 5 min and spit out. Repeat 1 to 4 times daily. Rinses are followed by a 20 to 30-min period of no food or fluid intake.
Ointments/gels • Tacrolimus ointment 0.1%* • Clobetasol propionate gel 0.05%* • Fluocinonide gel 0.05%* • Azathioprine gel (5 mg/ml in methylcellulose base)#	Apply a small amount of ointment/gel (“pea size”) directly to the lesion (s) for 10 to 15 min. Gauze occlusion may help to hold in place. Trays for gingival application can be fabricated. Applications are followed by a 20 to 30-min period of no food or fluid intake.

^*Supported by prospective clinical trial.

^#Supported by case series or retrospective studies.