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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Comput Toxicol. 2021 Sep 13;20:100188. doi: 10.1016/j.comtox.2021.100188

Table 3.

The hierarchical organization used to group histopathology terms of similar findings (and mechanism) for kidney toxicity; findings were extracted from preclinical toxicity study reports for regulatory submissions [36].

KIDNEY TOXICITY
General clusters Specific clusters
Tissue damage Necrosis
Degeneration
Nephropathy
Inflammatory changes Inflammation
Infiltration
Structural alterations Dilation
Adaption cell size/number
Accumulative lesions Accumulation
Vacuolation
Mineralization