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The hierarchical organization used to group histopathology terms of similar findings (and mechanism) for heart toxicity; findings were extracted from preclinical toxicity study reports for regulatory submissions [36].
| HEART TOXICITY | |
|---|---|
|
| |
| General clusters | Specific clusters |
|
| |
| Tissue damage | Necrosis Degeneration Myopathy |
| Inflammatory changes | Inflammation Infiltration |
| Structural alterations | Dilation Adaption cell size/number |
