Table 1.
QCA, coronary physiology and IVUS findings by Sex
| Variable | Total (n=277) | Women (n=212) | Men (n=65) |
|---|---|---|---|
|
| |||
| QCA findings | |||
| Minimal lumen diameter, mm | |||
| Baseline | 1.54±0.31 | 1.52±0.31 | 1.61±0.30 |
| After Ach 20µ dose | 1.41±0.35 | 1.42±0.33 | 1.39±0.42 |
| After Ach 50µ dose | 1.35±0.39 | 1.34±0.37 | 1.37±0.48 |
| After Ach 100µ dose | 1.37±0.43 | 1.37±0.40 | 1.37±0.54 |
| After Ach 200µ dose | 1.40±0.42 | 1.43±0.38 | 1.27±0.64 |
| After nitroglycerin 200µ dose | 1.69±0.30 | 1.66±0.29 | 1.76±0.32 |
| Endothelial dysfunction | 186 (68.1) | 140 (66.4) | 46 (74.2) |
| Max %MLD constriction* | 45±17 | 43±16 | 51±18 |
| Chest pain during Ach testing | 48 (17.5) | 38 (18.0) | 10 (15.6) |
| Ischemic ECG changes during Ach testing | 27 (9.8) | 23 (10.9) | 4 (6.2) |
| Complications during Ach testing | |||
| Atrioventricular block | 19 (6.9) | 14 (6.6) | 5 (7.8) |
| Bradycardia | 9 (3.3) | 6 (2.8) | 3 (4.7) |
| Atrial fibrillation | 3 (1.1) | 2 (0.9) | 1 (1.6) |
| Physiology findings | |||
| IMR | 19.65±8.77 | 19.96±9.19 | 18.62±7.19 |
| Microvascular dysfunction† | 61 (22.0) | 53 (25.0) | 8 (12.3) |
| CFR | 4.32±3.53 | 4.17±3.91 | 4.81±1.79 |
| CFR<2.0 | 20 (7.2) | 19 (9.0) | 1 (1.5) |
| CFR<2.5 | 43 (15.5) | 38 (17.9) | 5 (7.7) |
| FFR | 0.86±0.05 | 0.86±0.06 | 0.84±0.05 |
| FFR<0.80 | 30 (10.8) | 23 (10.8) | 7 (10.8) |
| IVUS findings | |||
| MPB, % | 39.9 [29.5, 52.2] | 38.9 [28.8, 50.8] | 44.9 [32.6, 57.4] |
| MLA, mm2 | 4.54±1.85 | 4.51±1.89 | 4.65±1.71 |
| Myocardial bridge | 164 (59.2) | 123 (58.0) | 41 (63.1) |
*
Data presented for patients with endothelial dysfunction;
†
defined as IMR≥25; CFR=coronary flow reserve; FFR=fractional flow reserve; IMR=index of microcirculatory resistance; QCA=Quantitative Coronary angiography;