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. 2022 Jun 3;28(6):1167–1177. doi: 10.1038/s41591-022-01829-9

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© The Author(s) 2022, corrected publication 2022

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Fig. 1 — a, PRINCE was a seamless phase 1b/2 study, with the phase 2 portion randomizing patients to treatment with nivo/chemo, sotiga/chemo or sotiga/nivo/chemo. b, CONSORT diagram of the phase 2 portion of the study. Patients enrolled in cohorts B2 and C2 during phase 1b were included in safety and/or efficacy analyses of the phase 2 portion.