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. 2022 Jun 17;13:3490. doi: 10.1038/s41467-022-31168-9

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

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Fig. 6 — a Co-staining of CB1 (green), DRD1 (red), and TH (purple) in the midbrain sections of homozygous floxed CB1 (Cnr1^fl/fl) and Drd1-Cre/Cnr1^fl/fl mice. Scale bar: 100 μm. More than five independent experiments were performed. b Rotarod locomotor skill training of Cnr1^fl/fl (n = 14, 7 M/7F) and Drd1-Cre/Cnr1^fl/fl (n = 12, 6M/6F) mice. Data were presented as mean ± SEM. Two-way ANOVA, genotype: F(1, 24) = 6.301, p = 0.0192. c Box and whiskers plot (the minimum, the 25th percentile, the median, the 75th percentile, and the maximum) of rotarod performance in the first and 10th trial on each day with the same cohorts of Cnr1^fl/fl (n = 14, 7M/7F) and Drd1-Cre/Cnr1^fl/fl (n = 12, 6M/6F) mice. Multiple unpaired t test, two-tailed, ^*p < 0.05, ^**p < 0.005.