Table 2.

AUC and the cutoff value of diagnostic indicators at the maximum of Youden index for GC metastases (N = 1667).

	AUC	95% CI	Cut-off	Sen	Spe	Youden index	PPV	NPV	P value
NLR	0.679	0.653–0.705	2.91	0.55	0.734	0.284	0.549	0.734	< 0.001
CEA	0.647	0.62–0.674	4.34	0.485	0.763	0.248	0.546	0.719	< 0.001
CA199	0.649	0.622–0.675	18.69	0.497	0.741	0.238	0.537	0.727	< 0.001
CA724	0.662	0.636–0.688	6.96	0.447	0.807	0.254	0.447	0.799	< 0.001
P1	0.716	0.691–0.74	0.39	0.538	0.75	0.333	0.568	0.758	0.209
P2	0.73	0.705–0.754	0.39	0.649	0.728	0.377	0.637	0.733	Ref

AUC area under receiver operating characteristics, CI confidence interval, Sen sensitivity, Spe specificity, PPV positive predictive value, NPV negative predictive value, P P value for comparison of AUC of reference with other indicators using DeLong’s test, P1 prediction probability obtained by binary logistic regression combining CEA, CA199, CA724, P2 prediction probability obtained by binary logistic regression combining CEA, CA199, CA724 and NLR, Ref reference.