Table 1.

Effect of crocin ± acrolein on anthropometric parameters in different studied groups.

	Control group		Cr group		Ac group (n10)	Oral-Cr/Ac group (n10)	ip-Cr/Ac group (n10)	p value
	Oral-saline (n5)	ip-saline (n5)	Oral-Cr (n5)	ip-Cr (n5)
Body weight (gm)	242.6 ± 21.8	232.6 ± 23.6	233.5 ± 14.7	229.2 ± 16.4	201.3 ± 11.3a	221.4 ± 24.5	232.5 ± 18.2c	0.0031
Wet lung weight (gm)	1.4 ± 0.2	1.5 ± 0.4	1.6 ± 0.4	1.4 ± 0.6	2.3 ± 0.7a	1.9 ± 0.6	1.8 ± 0.4	0.0183
Lung index*	6.4 ± 2.1	6.5 ± 1.3	7.2 ± 3.1	7.9 ± 3.5	10.2 ± 0.7a	8.1 ± 1.3c	6.9 ± 0.9c	0.0013
Dry lung weight (gm)	0.52 ± 0.14	0.49 ± 0.1	0.5 ± 0.04	0.53 ± 0.05	0.6 ± 0.2	0.56 ± 0.6	0.62 ± 0.7	0.9966
W/D %	3.3 ± 1.1	2.9 ± 1.5	3.2 ± 0.7	3 ± 0.4	6.4 ± 1.7b	4.7 ± 1.3c	3.9 ± 0.6d	< 0.001

One-way ANOVA, and Tukey HSD Post-hoc Test, p > 0.05: no significant differences, p < 0.05: significant differences.

*Lung index = wet lung weight (gr)/body weight (gr) × 1000; wet/ dry lung weight%.

^ap < 0.05 versus oral-saline group.

^bp < 0.001 significant versus oral-saline group.

^cp < 0.05 versus Ac group.

^dp < 0.001 significant versus Ac group.

^ep < 0.05 versus oral-Cr/Ac group.

^fp < 0.001 significant versus oral-Cr/Ac group.