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. 2022 Jun 17;13:3491. doi: 10.1038/s41467-022-31240-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Raw cryo-EM image of amyloid fibrils assembled from recombinant, full-length apo human SOD1 under reducing conditions. Enlarged section of a (right) showing a single protofilament intertwined into a left-handed helix, with a fibril full width of 12.3 ± 0.7 nm and a helical pitch of 144 ± 5 nm. The scale bar represents 50 nm. The helical pitch and fibril width were measured and expressed as the mean ± SD of values obtained in n = 8 biologically independent measurements. Source data are provided as a Source Data file. b Cross-sectional view of the 3D map of the SOD1 fibril showing a protofilament comprising the N-terminal part (left) and the C-terminal part (right), with an unstructured flexible region (bottom). Scale bars, 5 nm. c 3D map showing a single protofilament (in orchid) intertwined into a left-handed helix, with a fibril core width of ~11 nm and a half-helical pitch of 73.1 nm. d Enlarged section showing a side view of the density map. Close-up view of the density map in c showing that the subunit in protofilament stacks along the fibril axis with a helical rise of 4.82 Å. e Top view of the density map.