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. 2022 Jun 17;12:10237. doi: 10.1038/s41598-022-14284-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Catabolism of phenylalanine via the Ehrlich pathway is required for suppression of DEP-toxicity. (A) Catabolism of an α-amino acid via the Ehrlich pathway. (B) Wild type, aro8Δ and aro9Δ cells (Σ1278b background) growing in minimal urea medium in the absence (No AA) and presence of 5 mM phenylalanine (F)/methionine (M) were exposed to two-fold serial dilutions of DEP (maximum concentration at 25 mM). Normalized growth of various cultures is depicted as mean ± SD (N = 2).