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. 2022 Jun 17;8:20. doi: 10.1038/s41540-022-00230-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic representation of the workflow to generate CBDCA resistant clones from CAOV3. b Changes in IC50 of S clones (unselected) or R clones (8 at step 5 and 4 at step 15). Each IC50 is calculated from dose-response curves of 6 replicates and experiments repeated twice or more (dots). Boxes represent the top and bottom quartiles of the distribution and whiskers are extended to 1.5 time the interquartile range. c Doubling time measured over a 48 h time course—y axis cut for R18 (>100 h). d Counting of colonies formed in a period of 9 days after seeding 200 cells per well. Experimental replicates (N = 6) are shown. e Fraction of organoids (O), spheres (S) and cell aggregates (A) observed after 14 days growth in low adherence 3D culture model. For each sample (N = 8) and replicates (N = 2), the total number (point size) and relative abundance (Gibbs triangle coordinates) of each type of structure are indicated.